A Widespread Acquired Ailment, Nonalcoholic Fatty Liver Disease; Its Approaches Related to Nutritional Therapy (2024)

Mikiyas Amare Ayele, 2023

AbstractBackground: Non-alcoholic fatty liver disease, describes a condition where excess fat accumulates in the liver of people who consume little or no alcohol at all. NAFLD is generally asymptomatic, but some people may experience fatigue or discomfort in the upper right abdomen while NASH can cause symptoms such as fatigue, abdominal pain, and jaundice.Objective: To understand the role of diet and nutrition management for non-alcoholic fatty liver disease.Methodology: Systematic search strategy of PubMed, Google scholar and mendeley desktop Library was used to conducted articles.Conclusion: NASHis a type of NAFLD that involves inflammation and liver damage, in addition to fat accumulation. However, there have been times that a person with a simple fatty liver later developed NASH. These two conditions are quite difficult to manage because we can’t treat them with medications. The current modes of treatment for both of these conditions include lifestyle anddietary adjustments.Recommendation: The first line of action that recommended to treats NASH and NAFLD is weight loss. During weight loss the deposits of fats in the liver would also reduce. It can also help reduce inflammation and scarring. If peoples are either obese or overweight, they would need to make dietary changes and be physically active to achieve weight loss. Keywords: “role of diet and nutrition for non-alcoholic fatty liver disease, Nutrition management of Non-alcoholic Fatty liver, diet and NAFLD”.

Digestive Diseases and Sciences, 2000

Review article , 29

Abstract Background: Non-alcoholic fatty liver disease, describes a condition where excess fat accumulates in the liver of people who consume little or no alcohol at all. NAFLD is generally asymptomatic, but some people may experience fatigue or discomfort in the upper right abdomen while NASH can cause symptoms such as fatigue, abdominal pain, and jaundice. Objective: To understand the role of diet and nutrition management for non-alcoholic fatty liver disease. Methodology: Systematic search strategy of PubMed, Google scholar and mendeley desktop Library was used to conducted articles. Conclusion: NASH is a type of NAFLD that involves inflammation and liver damage, in addition to fat accumulation. However, there have been times that a person with a simple fatty liver later developed NASH. These two conditions are quite difficult to manage because we can’t treat them with medications. The current modes of treatment for both of these conditions include lifestyle and dietary adjustments. Recommendation: The first line of action that recommended to treats NASH and NAFLD is weight loss. During weight loss the deposits of fats in the liver would also reduce. It can also help reduce inflammation and scarring. If peoples are either obese or overweight, they would need to make dietary changes and be physically active to achieve weight loss. Keywords: “role of diet and nutrition for non-alcoholic fatty liver disease, Nutrition management of Non-alcoholic Fatty liver, diet and NAFLD”.

Clinical and Research Journal in Internal Medicine, 2020

Non-Alcoholic Fatty Liver Disease (NAFLD) is a condition that can develop into advanced liver disease. The NAFLD spectrum includes simple steatosis, non-alcoholic steatohepatitis (NASH), liver fibrosis, and liver cirrhosis to hepatocellular carcinoma. One of the underlying pathophysiologies is insulin resistance found in metabolic syndrome. People with metabolic syndrome are not always obese, and NAFLD can also be found in this group, known as lean NAFLD, which has different metabolic characteristics. Metabolic characteristics of lean NAFLD include high levels of transaminases and insulin, low insulin sensitivity, low fasting glucose, low necroinflammatory activity, and liver fibrosis. Some related factors are methionine and choline deficiency, excessive acyl-coA expression, and PNPLA3 gene polymorphism. Lean NAFLD is an interesting topic to discuss because practitioners' awareness of lean NAFLD is lower compared to obese patients. NAFLD is a risk factor for chronic diseases suc...

Endocrinology & Metabolic Syndrome, 2014

Nature Clinical Practice Endocrinology & Metabolism, 2007

Arquivos de gastroenterologia, 2019

The nonalcoholic fatty liver disease (NAFLD) affects approximately 20%-30% of general population and is even more prevalent among obese individuals. The risk factors mainly associated with NAFLD are diseases related to the metabolic syndrome, genetics and environment. In this review, we provide a literature compilation evaluating the evidence behind dietary components, including calories intake, fat, protein, fibers and carbohydrate, especially fructose which could be a trigger to development and progression of the NAFLD. In fact, it has been demonstrated that diet is an important factor for the development of NAFLD and its association is complex and extends beyond total energy intake.

Metabolic Syndrome and Related Disorders, 2012